RNF103-CHMP3 readthrough protein (RNF103-CHMP3)

RNF103-CHMP3 readthrough protein is a naturally occurring human fusion protein, produced by read-through transcription of the adjacent RNF103 (ring finger protein 103) and CHMP3 (charged multivesicular body protein 3) genes[1][3]. This fusion protein contains sequence and likely functional motifs derived from both parental proteins, with CHMP3 being a notable core component of the endosomal sorting required for transport complex III (ESCRT-III)[2][8]. ESCRT-III is essential for the formation of multivesicular bodies (MVBs), sorting of membrane proteins for lysosomal degradation, the terminal events of cytokinesis, and the budding of some enveloped viruses, including HIV-1[2][4][6][8]. Loss or dysregulation of this pathway is associated with diseases such as frontotemporal dementia, amyotrophic lateral sclerosis, cancer (via growth factor receptor regulation), and infection[2][4]. While no approved therapeutics currently target the RNF103-CHMP3 fusion, its function within ESCRT-III marks it as a potential drug target for modulating intracellular trafficking and membrane dynamics in disease contexts[4].

Other names

CGI149CHMP3NEDFRNF103-VPS24VPS24hVps24RNF103-CHMP3 proteinCharged multivesicular body protein 3Chromatin-modifying protein 3Neuroendocrine differentiation factorRNF103-CHMP3 read-throughRNF103-VPS24 readthroughVacuolar protein sorting-associated protein 24