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RNF216 intronic transcript 1 (non-protein coding) (RNF216-IT1)
- Target
- RNF216-IT1
- Molecular classification
- Long noncoding RNA (lncRNA), Intronic transcript, Other
01
Overview
RNF216 intronic transcript 1 (RNF216-IT1) is a long noncoding RNA transcribed from the intron of the RNF216 gene. Unlike its host gene RNF216, which encodes a well-characterized E3 ubiquitin ligase involved in immune regulation and cell signaling, RNF216-IT1 does not encode a protein. This lncRNA has been shown to be upregulated in osteosarcoma tumor tissue relative to normal bone and is predicted to localize to the ribosome. Although its precise biological function and disease relevance remain uncharacterized, differential expression in cancer suggests it may have a regulatory role similar to other intronic lncRNAs, such as modulation of RNA stability or translation. Currently, there are no known drugs, biomarkers, or safety concerns associated with RNF216-IT1[1][3].
- Other names
- RNF216 intronic transcript 1RNF216-IT1RNF216 intronic transcript 1 (non-protein coding)
02
Biological functions
At present, no well-characterized biological functions have been assigned to RNF216-IT1 specificallyOther (differentially expressed in cancer; possible regulatory roles typical for lncRNAs have not been directly demonstrated for RNF216-IT1)
03
Disease associations
Cancer (upregulated in osteosarcoma tissue compared to normal bone)Other (role in other diseases not established)
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