RNF217 antisense RNA 1 (RNF217-AS1)

RNF217 antisense RNA 1 (RNF217-AS1; also known as STL or six-twelve leukemia) is a long non-coding RNA gene transcribed in a head-to-head orientation with the protein-coding RNF217 gene. It shares a promoter and regulatory region with RNF217, a gene associated with leukemia through genomic aberrations and deregulated expression. Translocation events involving the RNF217/STL locus are implicated in hematologic malignancies, but RNF217-AS1 itself has no well-defined protein product or established biological function. Its significance is primarily as a genomic element in a leukemia-associated region rather than a classical molecular target for drug discovery. Do not confuse RNF217-AS1 (the non-coding RNA) with RNF217 (Ring Finger Protein 217, a protein-coding E3 ubiquitin ligase implicated in apoptosis and leukemia mechanisms). No direct evidence suggests RNF217-AS1 itself is a validated protein target, therapeutic target, or biomarker. RNF217-AS1 (STL, six-twelve leukemia) is a long non-coding RNA at a locus recurrently altered in leukemia, but currently it is not an established molecular therapeutic target nor is there sufficient evidence to assign it classical target biology beyond its genomic context.

Other names

STLSix-twelve leukemiaSTL (head to head)RNF217 antisense RNA 1 (head to head)