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Target intelligence / Profile preview
Rod-derived Cone Viability Factor (RdCVF)
- Target
- RdCVF
- Molecular classification
- Thioredoxin-like proteins, Trophic Factor, Secreted Protein
01
Overview
Rod-derived Cone Viability Factor (RdCVF) is a protein secreted by rod photoreceptors in the retina. Encoded by the *NXNL1* gene, it is a truncated thioredoxin that promotes the survival and function of cone photoreceptor cells, particularly under degenerative conditions such as retinitis pigmentosa (RP). RdCVF binds to Basigin-1 (BSG1) on cones, increasing glucose uptake and stimulating aerobic glycolysis. Loss of RdCVF due to rod degeneration contributes to secondary cone death in RP, making it a therapeutic target.
02
Mechanism of action
Enhances glucose uptake and aerobic glycolysis in cone photoreceptors via interaction with Basigin-1 (BSG1)
03
Biological functions
Cone photoreceptor survivalGlucose metabolism regulation in conesNeuroprotection
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Disease associations
Retinitis pigmentosaRetinal degeneration
05
Safety considerations
Potential for off-target effectsChallenges in large-scale production and purificationDelivery method optimization (gene therapy vs. protein injection)
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