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Target intelligence / Profile preview
Rod-derived Cone Viability Factor Long Form (RdCVFL)
- Target
- RdCVFL
- Molecular classification
- Enzyme, Thioredoxin-like oxidoreductase
01
Overview
Rod-derived cone viability factor long form (RdCVFL) is an enzymatically active thioredoxin protein encoded by the *NXNL1* gene. It functions primarily within photoreceptor cells as a redox-active enzyme, protecting them from oxidative stress and promoting cone survival, particularly in conditions of retinal degeneration such as retinitis pigmentosa. Its mechanism involves reducing oxidized cysteines on target proteins, such as pyruvate kinase M2 (PKM2), restoring glycolytic flux and cellular function.
- Other names
- NXNL1Nucleoredoxin-like 1RdCVF long form
02
Mechanism of action
Reduces oxidized cysteines in target proteins, thereby protecting cells from oxidative stress.
03
Biological functions
Redox homeostasisAntioxidant activityCone photoreceptor protectionCell survival
04
Disease associations
Retinitis pigmentosaInherited retinal degenerationOxidative stress-related diseases
05
Safety considerations
Potential for off-target effects due to redox activityNeed for targeted delivery to photoreceptor cells
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