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This entry refers to a method used in endodontic therapy where the root canal space is sealed using materials (commonly resin-based sealers) that harden through polymerization and adhere to tooth structure via micromechanical bonding. The process creates a seal by forming a hybrid layer—an interpenetrating network of adhesive polymer and demineralized dentin—which prevents bacterial infiltration and supports effective dental restoration[2][4][5][6][8][10]. Although clinically important, this is *not* a molecular or pharmacological target, but a procedure involving dental material science and adhesion mechanisms[5][7][10].
Polymerization of resin-based materials to form a solid matrix; Micromechanical interlocking of adhesive resins with demineralized dentin and enamel; Chemical bonding via functional monomers (e.g., 10-MDP bonding to hydroxyapatite)
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