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Target intelligence / Profile preview
ROS proto-oncogene 1 protein
- Molecular classification
- Receptor tyrosine kinase, Type I integral membrane protein, Insulin receptor family, Sevenless subfamily
01
Overview
The ROS proto-oncogene 1 encodes a type I integral membrane RTK involved in cellular signaling related to growth and differentiation. Its gene rearrangements drive oncogenesis across multiple solid tumors—most notably NSCLC—where they serve as actionable biomarkers for targeted TKI therapies such as crizotinib or repotrectinib. Diagnostic detection relies on sensitive immunohistochemical assays.
- Other names
- ROSc-RosMCF3
02
Mechanism of action
Tyrosine kinase inhibition
03
Biological functions
Cell growth and differentiation signalingSperm maturation
04
Disease associations
Cancer
05
Safety considerations
Resistance mutationsOff-target effects of TKIsDevelopment of secondary malignancies
06
Interacting drugs
Crizotinib
2 more in the full profile.
07
Biomarkers
ROS1 fusions (detected by IHC, FISH, or NGS)
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