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Target intelligence / Profile preview
ROS proto-oncogene 1 receptor tyrosine kinase (ROS1)
- Target
- ROS1
- Molecular classification
- Receptor Tyrosine Kinase, Type I integral membrane protein
01
Overview
ROS1 is a receptor tyrosine kinase involved in cell growth and differentiation. Somatic chromosomal rearrangements involving ROS1 result in fusion proteins that drive oncogenesis in various cancers, particularly NSCLC. Inhibitors like crizotinib and lorlatinib target aberrant ROS1 activity, but resistance mutations can emerge, necessitating the development of next-generation inhibitors.
- Other names
- ROS proto-oncogene 1, receptor tyrosine kinase
02
Mechanism of action
Inhibition of ROS1 tyrosine kinase activity
03
Biological functions
Growth factor receptorCell survivalCell growthCell proliferationCell differentiationEpithelial cell differentiation
04
Disease associations
CancerNon-small cell lung cancer (NSCLC)GlioblastomaCholangiocarcinoma
05
Safety considerations
Resistance mutationsOvercoming resistance with next-generation inhibitors
06
Interacting drugs
Crizotinib
1 more in the full profile.
07
Biomarkers
ROS1 rearrangementsROS1 fusionsD2113N mutation
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