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Target intelligence / Profile preview
ROS1 proto-oncogene receptor tyrosine kinase (ROS1)
- Target
- ROS1
- Molecular classification
- Receptor, Receptor Tyrosine Kinase (RTK), Type I integral membrane protein, Insulin receptor subfamily
01
Overview
ROS1 is a receptor tyrosine kinase that plays a role in epithelial cell differentiation and regionalization. Somatic chromosomal fusions involving ROS1 generate chimeric oncoproteins that drive various cancers, most notably non-small cell lung cancer (NSCLC). Tumors driven by oncogenic ROS1 fusions are sensitive to targeted therapies such as crizotinib.
- Other names
- c-ros oncogene 1, receptor tyrosine kinaseROS oncogene 1, receptor tyrosine kinaseROS1 receptor tyrosine kinase
02
Mechanism of action
Multi-targeted tyrosine kinase inhibitor
03
Biological functions
Epithelial cell differentiationRegionalizationSignal transductionCell survivalCell growthCell proliferationCell differentiation
04
Disease associations
CancerNon-small cell lung cancer (NSCLC)
05
Safety considerations
Resistance mutations during therapy progressionToxicities associated with TKIs
06
Interacting drugs
Crizotinib
07
Biomarkers
ROS1 fusionsROS1 rearrangements
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