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Target intelligence / Profile preview
ROS1 Proto-Oncogene Tyrosine-Protein Kinase (ROS1)
- Target
- ROS1
- Molecular classification
- Receptor, Receptor Tyrosine Kinase (RTK), Enzyme
01
Overview
ROS1 is a proto-oncogene encoding a receptor tyrosine kinase (RTK) that functions in cell differentiation, proliferation, and survival. Aberrant activation through gene fusions, particularly in NSCLC, leads to constitutive signaling and tumorigenesis. ROS1 fusions are targets for precision therapies, with inhibitors showing clinical benefit.
- Other names
- proto-oncogene tyrosine-protein kinase ROSROS proto-oncogene 1, receptor tyrosine kinase
02
Mechanism of action
Inhibition of ROS1 kinase activity, preventing downstream signaling and cell proliferation.
03
Biological functions
Cell DifferentiationCell ProliferationCell GrowthCell SurvivalSignal TransductionSperm Maturation
04
Disease associations
CancerNon-Small Cell Lung Cancer (NSCLC)Tumorigenesis
05
Safety considerations
Resistance to ROS1 inhibitorsOff-target effects of tyrosine kinase inhibitors
06
Interacting drugs
ROS1 inhibitors (e.g., Crizotinib, Entrectinib)
07
Biomarkers
ROS1 fusions (e.g., EML4-ROS1)ROS1 rearrangements
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