Rotavirus A outer capsid glycoprotein VP7 (serotype G1) (VP7 (G1))

Rotavirus A outer capsid glycoprotein VP7 (serotype G1) is a critical structural protein of the rotavirus virion, serving as a primary target for the host's neutralizing antibody response (UniProt P04502). It is a 37-kDa glycoprotein that forms the outer layer of the triple-layered viral particle and is essential for the attachment and penetration of the virus into intestinal enterocytes (PubMed: 22837210). The G1 serotype is historically the most prevalent globally, making it a central component in the formulation of major vaccines such as Rotarix and RotaTeq (CDC, 2023). These vaccines work by presenting the VP7 G1 antigen to the immune system to elicit protective immunity against natural infection. Monitoring the genetic diversity of the VP7 gene is vital for assessing vaccine effectiveness and the potential emergence of escape mutants (PubMed: 31235530). Therapeutic strategies primarily focus on preventative immunization, though research into monoclonal antibodies targeting VP7 continues for potential treatment applications.

Other names

VP7G1 glycoproteinOuter capsid protein VP7Glycoprotein 7VP7 serotype G1

Induction of neutralizing antibodies that target the VP7 protein to prevent viral attachment and entry into host cells.