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Target intelligence / Profile preview
Rotavirus capsid protein (VP6)
- Target
- VP6
- Molecular classification
- Structural viral protein, Capsid protein, Other
01
Overview
The rotavirus capsid is a complex, triple-layered structure composed of VP2 (core), VP6 (middle), and VP7 (outer) proteins. VP6, the most abundant and antigenically prominent capsid protein, forms the middle layer and is responsible for the group-specific serotyping of rotaviruses. The outer layer contains VP7, a glycoprotein, and spike-like protruding VP4, both crucial for virus infectivity and neutralization by host antibodies. Capsid proteins are structurally essential for viral integrity and play significant roles in virion assembly, immune recognition, and the efficacy of existing vaccines against rotavirus infection.
- Other names
- Rotavirus VP6Rotavirus major capsid proteinRotavirus VP2Rotavirus VP7
02
Mechanism of action
For vaccines: Induction of neutralizing antibodies primarily targeting VP7 and VP4, preventing virus entry and infection
03
Biological functions
Virion architecture/structural integrityAntigenicity (immunogenic target, mainly VP6, VP7, and VP4)Host cell recognition and immune response (mainly VP7 and VP4)Protective epitope presentation (especially VP7 and VP4)
04
Disease associations
Infection (rotavirus gastroenteritis)
05
Safety considerations
Vaccines using viral capsid proteins have been generally safe, but previous live vaccines carried a risk of intussusception (intestinal blockage)Live-attenuated vaccines can be problematic for immunocompromised patients
06
Interacting drugs
Rotarix (live attenuated)
3 more in the full profile.
07
Biomarkers
VP6 antigen is used as a diagnostic biomarker in stool-based rotavirus detection assays (ELISA and immunochromatographic tests)Antibodies against VP4 and VP7 are indicative of protective immunity
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