Target intelligence / Profile preview

Rotavirus Inner Capsid Protein VP6

Molecular classification: Structural protein, Capsid protein

Overview

Rotavirus inner capsid protein VP6 is the major structural protein forming the intermediate layer of the rotavirus triple-layered capsid. It plays a central role in virion architecture, stability, and function, acting as a physical adaptor between the outer and inner layers of the virus. It is essential for viral mRNA transcription, and antibodies against VP6 can inhibit this process. It is also a major antigenic target, making it a potential target for vaccine development.

Mechanism of action

Monoclonal antibodies against VP6 can neutralize rotavirus infection intracellularly and inhibit transcription.

Biological functions

Structural supportViral assemblymRNA transcriptionAdaptor function

Disease associations

Infection

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