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Target intelligence / Profile preview
Rotavirus outer capsid spike protein VP4, outer capsid glycoprotein VP7, and host cell surface glycans (VP4, VP7)
- Target
- VP4, VP7
- Molecular classification
- Viral structural protein, spike protein, glycoprotein, Glycan, carbohydrate moiety, cell surface receptor
01
Overview
Rotavirus is a non-enveloped, double-stranded RNA virus that causes severe gastroenteritis in humans. Its outer capsid contains spike-shaped VP4 proteins that protrude and bind to host cell surface glycans, initiating viral entry. VP7 is a glycoprotein that stabilizes the outer viral shell and is also a principal antibody target. Together, these components drive the specific binding and entry of rotavirus into host epithelial cells. Both VP4 and VP7 are targets for neutralizing antibodies, making them central to vaccine design. Host cell surface glycans act as receptors for virus attachment and define host specificity, species tropism, and pathogenicity.
- Other names
- Rotavirus spike protein VP4Rotavirus outer capsid glycoprotein VP7Rotavirus A VP4Rotavirus A VP7rotavirus receptor glycans
02
Mechanism of action
Vaccines and antibodies: Induction of neutralizing antibodies against VP4 and VP7, blocking virus attachment/entry and fusion. Glycan mimetics: Potential inhibitory mechanism via competitive binding on host cell glycans (experimental)
03
Biological functions
Virus attachmentmembrane penetrationhost range determinationneutralizationvirulenceVirion structural stabilizationimmune evasionVirus bindinghost specificity
04
Disease associations
Infection (specifically, rotavirus gastroenteritis)
05
Safety considerations
Intussusception (rare with live vaccines)Risk of disrupting normal cell signaling/adhesion or off-target effects if therapies are developed
06
Interacting drugs
rotavirus vaccines
07
Biomarkers
Detection of antibodies to VP4 and VP7 in patient sera for vaccination or infection statusPresence of specific host cell glycan profiles that permit rotavirus infection (research application)
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