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Target intelligence / Profile preview
Rotavirus Spike Protein Outer Capsid Protein (VP4)
- Target
- VP4
- Molecular classification
- Viral Structural Protein, Glycoprotein, Outer Capsid Protein
01
Overview
The rotavirus VP4 protein is an outer capsid spike protein found on the surface of mature rotavirus virions. It is a key structural and functional component, forming spikes that project from the viral particle's outer layer. VP4 mediates initial attachment to host epithelial cells by binding specific cell-surface glycans, facilitates penetration through cellular membranes, functions as a hemagglutinin, and interacts with the actin cytoskeleton for viroplasm assembly and virus egress.
- Other names
- Rotavirus Spike ProteinVP4
02
Mechanism of action
N/A
03
Biological functions
Cell AttachmentMembrane PenetrationHemagglutinationViroplasm AssemblyActin BindingReceptor BindingImmune Evasion
04
Disease associations
InfectionRotavirus Gastroenteritis
05
Safety considerations
Potential for escape mutantsVariability in glycan bindingHost range restrictions
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