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Target intelligence / Profile preview
Rotavirus Surface Antigen VP4 (VP4)
- Target
- VP4
- Molecular classification
- Viral Surface Antigen, Spike Protein
01
Overview
Rotavirus surface antigen VP4 is a spike-forming protein located on the outer capsid of rotaviruses. It mediates the virus's attachment to host epithelial cell receptors and facilitates viral entry through membrane penetration. VP4 is cleaved into VP8* (receptor binding) and VP5* (membrane penetration) subunits. It is a key target for vaccine development due to its ability to induce strong mucosal and systemic immune responses. VP4 also contains an actin-binding domain that promotes actin cytoskeleton remodeling for nonlytic virus exit.
- Other names
- Rotavirus Spike Protein VP4VP4 spike proteinRotavirus attachment protein VP4Rotavirus hemagglutinin
02
Mechanism of action
Antibody neutralization of viral attachment and entry
03
Biological functions
Host cell attachmentMembrane penetrationViral entryActin cytoskeleton remodelingImmune response induction
04
Disease associations
InfectionRotavirus gastroenteritis
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