Target intelligence / Profile preview

Rotavirus Surface Antigen VP7 (VP7)

Target: VP7
Molecular classification: Glycoprotein, Viral Capsid Protein, Surface Antigen

Overview

Rotavirus surface antigen VP7 is a major glycoprotein component of the outer capsid layer of rotaviruses. It plays a critical role in viral infectivity, immune recognition, and serves as a principal target for neutralizing antibodies during infection. VP7 forms trimers stabilized by calcium ions, and its removal leads to dissociation into monomers, which is an essential step for viral uncoating and cell entry. It is highly immunogenic and a promising candidate for subunit vaccine design.

Mechanism of action

Neutralization by antibodies

Biological functions

Viral attachmentViral entryImmune recognitionNeutralization target

Disease associations

Infection

Safety considerations

Antigenic variability may reduce vaccine efficacy

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