Target intelligence / Profile preview

Rotavirus Viral Protein 6 (VP6)

Target: VP6
Molecular classification: Structural Protein, Capsid Protein

Overview

The rotavirus VP6 protein is a major structural component of the rotavirus capsid, forming the middle layer. It is highly abundant, conserved, and immunogenic, making it a key target for diagnostics and vaccine development. It acts as a physical adaptor between the outer and inner capsid layers and is essential for virion organization and transcription. VP6 elicits strong cross-protective immunity, making it a potential vaccine candidate.

Mechanism of action

Monoclonal antibodies against VP6 can inhibit transcription

Biological functions

Virion AssemblyGenome PackagingTranscriptionImmune Response

Disease associations

InfectionGastroenteritis

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