Target intelligence / Profile preview

Rotavirus VP4 (VP4)

Target: VP4
Molecular classification: Viral structural protein

Overview

VP4 is an outer capsid spike protein of Rotavirus that mediates attachment to host cell receptors and facilitates membrane penetration during entry. It undergoes tryptic cleavage into VP8* and VP5*. VP8* binds sialic acid on host cells and VP5* is involved in membrane permeabilization. It also contains an actin-binding domain (RV-ABD) that interacts with actin cytoskeleton to promote virus exit.

Mechanism of action

N/A

Biological functions

Cell attachmentMembrane penetrationActin bindingCell entry

Disease associations

InfectionGastroenteritis

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