Rotavirus VP7 G2 glycoprotein (VP7 G2)

Rotavirus VP7 G2 glycoprotein is a major structural component of the outer capsid of Group A Rotaviruses, specifically those belonging to the G2 genotype (UniProt P04502). It is a 37-kDa calcium-binding protein that forms the smooth outer shell of the triple-layered infectious particle (PMID: 18462440). VP7 plays a critical role in viral entry by facilitating the attachment and subsequent penetration of the host cell membrane (PMID: 25824474). As one of the two primary antigens—along with VP4—that define the viral serotype and induce neutralizing antibodies, it is a central target for vaccine development (CDC, 2023). The G2 genotype is frequently associated with the P[4] genotype and is a common cause of severe diarrhea in infants worldwide. Vaccines like RotaTeq specifically include a G2 reassortant to provide immunity against this strain, while others rely on cross-neutralization (PMID: 17484215). Monitoring variations in the VP7 G2 protein is essential for tracking vaccine efficacy and the emergence of escape mutants. The protein's stability is highly dependent on calcium concentrations, and its loss triggers the uncoating process necessary for viral replication (PMID: 12610144).

Other names

Outer capsid glycoprotein VP7G2-type VP7Glycoprotein 7VP7 antigen

Induction of G2-specific neutralizing antibodies that bind to the VP7 surface, preventing viral attachment to host cells and inhibiting the calcium-dependent uncoating of the viral capsid.