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Target intelligence / Profile preview
Round spermatid basic protein 1 (RSBN1)
- Target
- RSBN1
- Molecular classification
- Enzyme, Histone demethylase, Chromatin modulator
01
Overview
Round spermatid basic protein 1 (RSBN1) is a histone demethylase, also known as KDM9, that primarily removes methyl groups from dimethylated and trimethylated lysine 20 on histone H4 (H4K20me2/3), thereby modulating chromatin structure and contributing to epigenetic regulation during sperm cell development[1][2][4]. RSBN1 is expressed predominantly in round and elongated spermatids but is also found in brain and ovary tissue[1]. The demethylation function of RSBN1 is critical for chromosome architecture and genome stability in germ cells, making it important for proper meiotic progression, though it is not considered a direct therapeutic target nor associated with specific diseases[1]. Alternative names for RSBN1 include KDM9, FLJ11220, and ROSBIN[5][6].
- Other names
- KDM9Lysine-specific demethylase 9FLJ11220ROSBINRosbin protein
02
Biological functions
Histone demethylation (specifically dimethyl- and trimethyl-lysine 20 on histone H4)Regulation of chromosome architectureEpigenetic regulation during spermatogenesisMeiotic and post-meiotic progression in germ cells
03
Disease associations
Other (No known direct disease association; may be involved in sperm development, possible links to genome integrity and neuronal cell regulation, but no established disease roles)
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