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Target intelligence / Profile preview
Roundabout Guidance Receptor 2 (ROBO2)
- Target
- ROBO2
- Molecular classification
- Receptor, Transmembrane receptor
01
Overview
Roundabout guidance receptor 2 (ROBO2) is a transmembrane protein that functions primarily as a receptor for the SLIT family of proteins, especially SLIT2. It plays a crucial role in axon guidance and cell migration during nervous system development. In vertebrates, it prevents axons from recrossing the midline by responding to Slit ligands secreted by floor plate cells at the CNS midline. Beyond initial wiring, ROBO2 also contributes to lateral pathway formation, cell migration, synaptogenesis, and maintenance of inhibitory synapses in adult brain regions. Alterations or mutations affecting ROBO2 have been implicated in several neurodevelopmental disorders.
02
Mechanism of action
Repulsive guidance cue signaling via SLIT ligand binding.
03
Biological functions
Axon guidanceCell migrationSynaptogenesisSynaptic plasticityMaintenance of inhibitory synapses
04
Disease associations
Neurodevelopmental disordersPsychopathy
05
Safety considerations
Potential disruption of excitatory/inhibitory balance in brain regions.Possible developmental defects if targeted during critical periods.
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