Roundabout homolog 1 receptor (ROBO1)

Roundabout homolog 1 receptor (ROBO1) is a transmembrane protein encoded by the *ROBO1* gene. It belongs to the immunoglobulin superfamily and functions primarily as an axon guidance receptor that mediates cellular responses to molecular cues—most notably through binding SLIT family ligands—to regulate neuronal navigation across the midline during central nervous system development. In addition to its critical role in neural patterning and cell adhesion, ROBO1 has been implicated in regulating cell proliferation and migration outside of neural tissues. Clinically, genetic variants or disruptions of *ROBO1* have been associated with neurodevelopmental disorders such as dyslexia and may influence susceptibility to certain cancers through pathways affecting cellular growth control[1][2][3][5].

Other names

Roundabout guidance receptor 1ROBO1Drosophila roundabout homolog 1 (in reference to evolutionary conservation)

(There are no approved drugs targeting this molecule; however, experimental modulation would likely involve altering axon guidance or cell migration by interfering with Slit–ROBO signaling.)