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Target intelligence / Profile preview
Royalactin (MRJP1)
- Target
- MRJP1
- Molecular classification
- Growth factor, Protein
01
Overview
Royalactin (also referred to as Major Royal Jelly Protein 1 or MRPJ1) is a ~57 kDa protein found predominantly in royal jelly secreted by worker bees. It promotes differentiation of bee larvae into queens rather than workers, increases body size and ovary development, and shortens developmental time for queen bees. Royalactin acts via the epidermal growth factor receptor (EGFR) signaling pathway and modulates Insulin/IGF and mTOR pathways. It is being investigated for potential roles as an anti-aging agent and for immunomodulatory properties related to cancer.
- Other names
- Major Royal Jelly Protein 1
02
Mechanism of action
Acts via the epidermal growth factor receptor (EGFR) signaling pathway. Activates downstream effectors such as p70 S6 kinase and mitogen-activated protein kinase (MAPK). Influences juvenile hormone levels affecting ovary development.
03
Biological functions
Cell differentiationCell growthOvary developmentActivation of EGFR signalingModulation of Insulin/IGF signalingmTOR pathway modulation
04
Disease associations
AgingSarcopeniaCancer (potential immunomodulatory effects)
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