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RP11-295D4.3
- Molecular classification
- Long non-coding RNA
01
Overview
RP11-295D4.3 (ENSG00000280063) is a long non-coding RNA of the TEC (To be Experimentally Confirmed) category. It has been observed to function as an enhancer-like RNA, influencing gene expression by targeting promoter regions and recruiting transcription factors, splicing factors, and RNA binding proteins. It shows differential expression in several types of cancer and may be involved in chromatin and transcription regulation through interactions with proteins such as INO80, SETD5, TAF1, BPTF, KMT2D, SETD2, EP300, CREBBP, and various transcription and splicing factors[1]. There is no current evidence it is a direct therapeutic target, nor are there clinically validated pharmacological agents or biomarker uses known.
- Other names
- ENSG00000280063
02
Biological functions
Regulation of gene expression (as enhancer lncRNA)Recruitment of transcription factorsRegulation of alternative splicing (interaction with splicing factors)
03
Disease associations
Cancer (noted as differentially expressed in tumor types including cholangiocarcinoma and rectal adenocarcinoma)
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