RPL17-C18orf32 readthrough (RPL17-C18orf32)

The RPL17-C18orf32 readthrough is a product of natural readthrough transcription between the human RPL17 gene, which encodes a component of the 60S ribosomal subunit, and the adjacent C18orf32 gene. The resulting transcripts encode proteins that incorporate most of the RPL17 sequence but terminate with a distinct, frameshifted C-terminal extension derived from C18orf32 exons. While RPL17 is essential for ribosomal assembly and protein translation, and its mutations are linked to disorders such as Diamond-Blackfan anemia, the physiological and pathological roles of the RPL17-C18orf32 chimeric product are largely uncharacterized and not currently targeted by therapeutics[3][4][5][2][1].

Other names

RPL17-C18orf32 proteinRPL17C18orf3260S ribosomal protein L17Large ribosomal subunit protein uL22