RPL36A-HNRNPH2 readthrough (RPL36A-HNRNPH2)

RPL36A-HNRNPH2 readthrough is a locus on chromosome X formed by natural read-through transcription between the adjacent genes encoding ribosomal protein L36a and heterogeneous nuclear ribonucleoprotein H2[4][5]. The resulting transcript produces a protein similar to RPL36A, a ribosomal structural protein involved in protein synthesis[2][4][5]. Alternatively spliced transcript variants exist. The locus is implicated as a genomic region associated with Fabry disease and intellectual developmental disorder, though no evidence exists for direct drug targeting or receptor activity[1][5]. Regulatory elements in this region may affect the expression of disease-relevant neighboring genes such as *GLA* (alpha-galactosidase A)[1]. In summary, **RPL36A-HNRNPH2 readthrough** is best classified as a structural ribosomal protein from a readthrough locus with disease associations, but it does not conform to the usual categories of therapeutic drug targets, such as receptor, enzyme, or ion channel[1][2][4][5].

Other names

RPL36A-HNRNPH2 proteinRPL36A-HNRNPH2 geneRibosomal protein L36a-Heterogeneous nuclear ribonucleoprotein H2 readthroughH0Y3V9 protein (UniProt accession)H7BZ11 protein (UniProt accession)