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Target intelligence / Profile preview
Rpp21 domain-containing TRIM protein (TRIM39-RPP21)
- Target
- TRIM39-RPP21
- Molecular classification
- Other
01
Overview
TRIM39-RPP21 is a readthrough fusion protein in humans containing the N-terminal tripartite motif (RING, B-box, coiled-coil) of TRIM39 and the C-terminal portion of RPP21, a ribonuclease P subunit. It is transcribed in tissues such as human fetal lung and smooth muscle cells, localizes to intranuclear speckles, and is phosphorylated by cGMP-dependent protein kinase I (PKGI). While it retains characteristics of E3 ubiquitin ligases and RNA-protein complexes, its exact biological role is still poorly understood and it is not established as a recognized drug target or disease biomarker.
- Other names
- TRIM39-RPP21TRIM39RTRIM39-RPP21 proteinRpp21 domain-containing TRIM proteinTRIM39-RPP21 read-through transcript
02
Biological functions
Forms an intranuclear speckled pattern and may participate in protein-protein interactions relevant for cellular homeostasisContains domains linked to ubiquitination (E3 ligase activity from TRIM family) and RNA processing (RPP21, ribonuclease P component)
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