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RPP38 divergent transcript (RPP38-DT)
- Target
- RPP38-DT
- Molecular classification
- Long non-coding RNA (lncRNA), antisense transcript
01
Overview
RPP38 divergent transcript (RPP38-DT, also known as C10orf111) is a human gene located at chromosome 10 (10p13), encoding a long non-coding RNA (lncRNA). The gene is transcribed in an antisense orientation near the RPP38 coding gene (hence "divergent transcript") and is classified as a lncRNA due to low or absent protein coding potential. Like other divergent lncRNAs, RPP38-DT may participate in transcription regulation, chromatin remodeling, or modulation of RNA splicing, although its specific biological functions and clinical relevance remain uncharacterized. Some evidence suggests that RPP38-DT can be differentially expressed in response to DNA damage, such as ionizing radiation, and may be associated with cellular stress response and cancer biology, but its role as a therapeutic target, biomarker, or drug-interacting molecule is not established.
- Other names
- C10orf111MGC35468bA455B2.4RPP38 divergent transcript proteinuncharacterized protein C10orf111
02
Biological functions
Regulation of gene expression through mechanisms such as recruitment of transcription factors, modulation of alternative splicing, chromatin modificationfunctions typical of lncRNAs are suggested but not fully established for RPP38-DT specifically
03
Disease associations
May be implicated in cancer (differential expression detected in tumor versus normal samples)DNA damage responsepotentially developmentspecificity and mechanisms remain poorly defined
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