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rRNA-processing protein UTP23 homolog (UTP23)

Target: UTP23
Molecular classification: Other (nucleolar protein), Small subunit (SSU) processome component, Evolutionarily conserved protein involved in ribosome biogenesis

Overview

UTP23 is a nucleolar protein that is a structural component of the small subunit (SSU) processome, which mediates early steps in the biogenesis of the 40S ribosomal subunit. It contains a degenerate PIN domain and a unique CCHC-type Zn finger motif, but lacks canonical nuclease activity, functioning instead as a structural factor in ribosome assembly. UTP23 associates specifically with snR30 snoRNA and is required for early processing of 18S rRNA at key cleavage sites (A0, A1, A2). It is evolutionarily conserved, essential for proper cell growth and ribosome maturation, but not considered a druggable or clinical therapeutic target. While implicated in the pathology of colorectal adenocarcinoma, it is not a primary disease gene or biomarker in current medical use.

Other names: UTP23UTP23 small subunit processome componentrRNA-processing protein UTP23 homologC8orf53MGC14595Chromosome 8 open reading frame 53

Biological functions

rRNA processing (specifically for 18S rRNA)Ribosome biogenesismRNA 3'-UTR bindingmRNA 5'-UTR bindingNucleolar localization

Disease associations

Colorectal adenocarcinoma (implicated but not established as direct driver or therapeutic target)

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