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Target intelligence / Profile preview
RUN and SH3 domain containing 1 (RUSC1)
- Target
- RUSC1
- Molecular classification
- Adaptor protein, Cytoskeletal-associated protein, Other
01
Overview
RUN and SH3 domain containing 1 (RUSC1) is an adaptor protein with actin-binding properties, involved in protein polyubiquitination and vesicular trafficking. It associates with the AP-4 adaptor complex, influencing neuronal vesicle transport and differentiation, specifically via regulation of NGF-dependent neurite outgrowth and the MAPK and NF-κB pathways. While not a direct drug target, its antisense transcript RUSC1-AS1 modulates major cancer-related signaling pathways (Wnt/β-catenin, PI3K/AKT), contributing to tumor progression and serving as a potential cancer biomarker. RUSC1 mutations are linked to autosomal recessive hereditary spastic paraplegia.
- Other names
- NESCANescaAP-4 complex accessory subunit RUSC1RUN and SH3 domain-containing protein 1New molecule containing SH3 at the carboxy-terminus
02
Biological functions
Actin bindingProtein polyubiquitinationVesicular traffickingNGF-dependent neurite outgrowthRegulation of neuronal differentiationNF-κB pathway modulation
03
Disease associations
Hereditary spastic paraplegia (Spastic Paraplegia 50, Autosomal Recessive)Cancer (through antisense RNA RUSC1-AS1's regulatory roles in breast cancer and osteosarcoma)
04
Biomarkers
RUSC1-AS1
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