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Target intelligence / Profile preview
Runt-related Transcription Factor 1 (RUNX1)
- Target
- RUNX1
- Molecular classification
- Transcription factor, Runt-related transcription factor family, CBFα
01
Overview
Runt-related transcription factor 1 (RUNX1) is a master regulatory protein crucial for blood cell development but also involved more broadly across tissues including bone formation and heart tissue remodeling. Its dysregulation—by mutation or chromosomal rearrangement—is strongly linked to several cancers including acute myeloid leukemia. Experimental small-molecule inhibitors exist but none are yet clinically approved.
- Other names
- AML1CBFA2Acute Myeloid Leukemia 1 proteinCore-binding factor subunit alpha-2
02
Mechanism of action
Inhibition of RUNX1 transcriptional activity
03
Biological functions
Hematopoiesis regulationImmune modulationBone formationNeuronal developmentRegulation of gene expression
04
Disease associations
Acute Myeloid LeukemiaMyelodysplastic SyndromeBreast CancerAutoimmune DiseasesCardiac HypertrophyHeart Failure
05
Safety considerations
Potential for off-target effects due to broad role in gene regulationHematological toxicities
06
Interacting drugs
Ro24-7429
1 more in the full profile.
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