Runt-related transcription factor 3 (RUNX3)

Runt-related transcription factor 3 (RUNX3) is a member of the runt domain-containing family of transcription factors, encoded by the RUNX3 gene in humans. RUNX3 forms a heterodimer complex that binds to specific DNA sequences in enhancers and promoters, regulating gene transcription by either activating or repressing target genes[1]. It functions as a crucial tumor suppressor, with frequent deletion, promoter methylation, or transcriptional silencing observed in various human cancers[1][5]. RUNX3 is involved in the regulation of cell cycle arrest, apoptosis, p53 stability, and immune function, including specific regulation of natural killer (NK) cell receptors[1][2][6]. While no direct drugs target RUNX3, its loss of expression or function is an established biomarker in oncology, and RUNX3 methylation in blood or tissue is explored for early cancer detection and monitoring[5]. It is not a receptor, enzyme, or ion channel, but a transcription factor influencing multiple key cellular processes and disease pathways.

Other names

AML2CBFA3PEBP2 alpha CPEBP2aCRP3-398I9.1FLJ34510MGC16070acute myeloid leukemia gene 2core-binding factor, runt domain, alpha subunit 3

Not applicable (no direct drugs targeting RUNX3 identified)