RUNX1 partner transcriptional co-repressor 1 (RUNX1T1)

RUNX1 partner transcriptional co-repressor 1 (RUNX1T1), also known as ETO or MTG8, is a zinc finger transcriptional corepressor that recruits histone deacetylase complexes to DNA and represses gene expression[1][2][4]. It plays diverse regulatory roles in cell fate decisions, particularly in hematopoiesis, neuronal differentiation, adipogenesis, angiogenesis, and alternative RNA splicing[2][3][4]. RUNX1T1 is most noted for its role in the pathogenesis of acute myeloid leukemia (AML), especially in cases involving the t(8;21)(q22;q22) chromosomal translocation, which creates the RUNX1-RUNX1T1 fusion oncoprotein that drives leukemic transformation by repressing differentiation genes and reorganizing chromatin structure[1][3][4]. Beyond leukemia, RUNX1T1 influences development, tissue differentiation, and may participate in the pathogenesis or progression of various solid tumors, acting as a biomarker, suppressor, or positive regulator in a context-dependent manner[2].

Other names

Protein CBFA2T1AML1T1CBFA2T1CDRETOMTG8ZMYND2Cyclin-D-related proteinEight twenty one proteinProtein ETOProtein MTG8Zinc finger MYND domain-containing protein 2AML1-MTG8RUNX1 translocation partner 1Acute myelogenous leukemia 1 translocation 1Myeloid translocation gene on 8q22

Inhibition of histone deacetylase recruitment; Disruption of RUNX1T1 fusion protein-mediated transcriptional repression (for HDAC inhibitors); Potential inhibition or silencing via siRNA