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Target intelligence / Profile preview
RUNX3 antisense RNA 1 (RUNX3-AS1)
- Target
- RUNX3-AS1
- Molecular classification
- Long noncoding RNA (lncRNA), Antisense RNA, Regulatory RNA
01
Overview
RUNX3 antisense RNA 1 (RUNX3-AS1) is a long noncoding RNA (lncRNA) transcribed from the antisense strand opposite the RUNX3 gene locus[7]. Like other antisense lncRNAs, RUNX3-AS1 is implicated in the regulation of its sense gene (RUNX3), potentially through epigenetic, transcriptional, or post-transcriptional mechanisms[9]. Dysregulation of RUNX3-AS1 expression has been reported in various cancers, where it may contribute to tumor progression or suppression depending on cellular context. Its function and mechanisms are largely under active research, and it has been proposed both as a potential cancer biomarker and a future candidate for therapeutic intervention, but there are currently no approved targeted drugs[7][9].
- Other names
- RUNX3 Antisense RNA 1RUNX3-AS1
02
Biological functions
Epigenetic regulationTranscriptional regulation of RUNX3Post-transcriptional gene regulationPossible modulation of cell proliferation, apoptosis, and cancer-related pathways
03
Disease associations
CancerTumor progression/metastasis (context-dependent)
04
Safety considerations
Therapeutic targeting of lncRNAs poses challenges such as delivery, off-target effects, and functional redundancy.
05
Biomarkers
Possible biomarker for cancer diagnosis, prognosis, or therapeutic response, as abnormal expression of RUNX3-AS1 has been associated with some tumors
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