RuvB-like AAA ATPase 1 (RUVBL1)

RuvB-like AAA ATPase 1 (RUVBL1) is an evolutionarily conserved eukaryotic AAA+ ATPase that forms part of several multi-protein complexes involved in essential cellular processes, such as chromatin remodeling (including the INO80, TIP60, and SWR1 complexes), transcriptional regulation, DNA damage repair, cell cycle control, and apoptosis. Structurally, RUVBL1 assembles into multimeric (hexameric or dodecameric) rings, often in association with its homolog RUVBL2, providing both molecular motor (ATPase) and DNA/RNA binding capacity critical for the activity of chromatin remodelers and chaperone assemblies. RUVBL1 is implicated in cancer due to its overexpression and interaction with oncogenic pathways, such as c-Myc and Wnt, and is regarded as a prospective therapeutic target in oncology and other diseases where its regulatory functions are dysregulated. Its broad involvement in fundamental processes also raises safety concerns for targeted therapy, underscoring the need for specific targeting strategies to minimize adverse effects on normal cell physiology.

Other names

RuvB-like 1INO80HNMP238TIP49TIP49A49 kDa TBP-interacting proteinECP-54NMP 238TAP54-alphaRVB1TIP49aPontin52ECP54TIH1Rvb154 kDa erythrocyte cytosolic proteinINO80 complex subunit HNuclear matrix protein 238Pontin 52TIP60-associated protein 54-alphapontin49 kDa TATA box-binding protein-interacting proteinRuvB (E coli homolog)-like 1epididymis secretory sperm binding protein

Small molecules and inhibitors (e.g., ATP analogs, cordycepin for RUVBL2) can modulate ATPase activity, affect chromatin remodeling, and destabilize oncogenic complexes Inhibition affects assembly/activity of protein complexes (R2TP, INO80, mTOR), disrupts cell cycle, potentially leading to anti-proliferative effects in cancer