RuvB-like ATPase 2 (RUVBL2)

RuvB-like ATPase 2 (RUVBL2) is a highly conserved AAA+ ATPase and helicase that functions as an essential subunit of several nuclear protein complexes, notably the INO80 and NuA4 chromatin remodeling complexes and the R2TP chaperone. It forms hexameric or dodecameric assemblies, often with its paralog RUVBL1, and is critical for ATP-dependent processes such as DNA unwinding, chromatin remodeling, and transcription regulation. RUVBL2 is a coactivator of RNA polymerase II–dependent transcription and supports the assembly and function of large macromolecular complexes involved in cell cycle progression, DNA repair, and oncogenic transformation[1][2][3][4][5]. RUVBL2 is overexpressed in a variety of cancers, where it regulates oncogene and proto-oncogene function; consequently, it is being investigated as a cancer therapeutic target. Cordycepin has been identified as a small molecule inhibitor of RUVBL2, offering proof of druggability[3]. Given its broad cellular functions and essentiality, therapeutic targeting of RUVBL2 requires careful consideration of potential safety liabilities.

Other names

RuvB-like 2INO80JTIP48TIP49BCGI-4648 kDa TBP-interacting proteinECP-51Reptin 52TAP54-betaRVB2TIP49bReptin52ECP51TIH251 kDa erythrocyte cytosolic proteinINO80 complex subunit JRepressing pontin 52TIP60-associated protein 54-betareptinRvb2

Inhibition of ATPase activity leading to impaired chromatin remodeling and transcriptional regulation Disruption of multi-protein complex assembly