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Target intelligence / Profile preview
RWD domain-containing protein 1 (RWDD1)
- Target
- RWDD1
- Molecular classification
- Other (RWD domain-containing protein, member of intrinsically unstructured protein family), Not classified as a receptor, enzyme, transporter, ion channel, or transcription factor
01
Overview
RWD domain-containing protein 1 (RWDD1) is a human protein and member of the RWD domain protein family, and may be a type of intrinsically unstructured protein. RWDD1 is ubiquitously expressed in a wide range of tissues, and its key biological role is to protect DRG2 from proteolytic degradation. It also participates in the regulation of androgen receptor activity and is implicated in cytoplasmic translation. Reduced RWDD1 expression has been observed in aged or oxidatively stressed thymic tissue in mice. There is an association of RWDD1 with Potocki-Lupski syndrome at the genetic level, but its direct involvement in human disease is not established. Currently, no drugs target RWDD1, and it is not considered a traditional therapeutic target such as a receptor, enzyme, or transporter.
- Other names
- RWDD1DFRP2CGI-24PTD013DRG family-regulatory protein 2RWD domain-containing protein 1
02
Mechanism of action
Not applicable; no drugs or tool compounds reported to act directly on this protein.
03
Biological functions
Protects DRG2 (developmentally regulated GTP-binding protein 2) from proteolytic degradationRegulates androgen receptor activityParticipates in cytoplasmic translationInvolved in cell aging, cellular response to oxidative stress, and cellular response to testosterone stimulus
04
Disease associations
Potocki-Lupski syndrome (gene association, unclear functional implication)Thymus aging (reduced RWDD1 expression in aged or oxidatively stressed mouse thymus)No proven roles in major disease classes such as cancer, inflammation, neurodegenerative disease, cardiovascular disease, or infection
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