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RWD domain-containing protein 2A (RWDD2A)

Target: RWDD2A
Molecular classification: Other (RWD domain-containing protein; not an enzyme, receptor, ion channel, transporter, or transcription factor; also considered part of the ubiquitin-conjugating enzyme superfamily by structure only, not direct function)

Overview

RWD domain-containing protein 2A (RWDD2A) is a small human protein characterized by an N-terminal RWD domain, which is part of a superfamily structurally related to ubiquitin-conjugating enzymes, though it lacks catalytic activity and functions mainly in protein-protein interactions[2][3]. RWDD2A also possesses a C-terminal domain of unknown function that structurally resembles the C-terminal region of Prp3, a protein involved in spliceosomal assembly for pre-mRNA splicing, hinting at possible RNA-associated roles[2]. The biological function of RWDD2A remains unclear; its domains are associated with, but not directly responsible for, sumoylation and ubiquitination pathways[1][2]. There is no current evidence that RWDD2A plays a well-established role as a disease-related target or as a direct drug target[3].

Other names: RWDD2ARWDD2MGC13523dJ747H23.2RWD domain containing 2RWD domain-containing protein 2A

Biological functions

Protein-protein interaction (via RWD domain)possible involvement in pre-mRNA splicing due to C-terminal domain structural similarity to Prp3potential protein modification pathway association (SUMOylation/ubiquitination, but not as a canonical enzyme)

Disease associations

Other (no strong disease association or validated disease involvement evidence in current data)

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