RWD domain-containing protein 2B (RWDD2B)

RWD domain-containing protein 2B is a human protein encoded by the RWDD2B gene (commonly known as C21orf6 or GL011 as aliases)[9]. It contains an RWD domain, a conserved motif involved in protein-protein interactions typically found in proteins that regulate ubiquitin or SUMO conjugation pathways[7]. RWDD2B’s precise biological function remains incompletely characterized; however, it is believed to play a role in key cellular processes through its unique RWD domain, acting as a scaffold or adaptor in multiprotein complexes[3][9]. Preliminary research and AI-driven molecular modeling position RWDD2B as a prospective therapeutic target, especially for conditions involving dysregulated cell signaling, but there is as yet no direct evidence of it acting as a receptor, enzyme, or established therapeutic target in clinical use[3]. Key points: - RWDD2B is classified as an "Other" molecular family member, being an RWD domain-containing adaptor protein rather than a classic receptor, enzyme, ion channel, or transporter[7][9]. - Its primary role is likely in mediating protein-protein interactions, possibly in ubiquitin-proteasome or SUMOylation pathways (by analogy to other RWD domain-containing proteins)[7][5]. - It is considered a prospective or potential therapeutic target and is of interest for further drug discovery efforts using modern AI and protein structural biology, but no drugs or standard biomarker roles are currently known[3][9]. - Expression data indicate it is present in various tissues, but clinical relevance remains to be clarified[4][9].

Other names

C21orf6GL011RWDD2BRWD domain containing 2BRWD domain-containing protein 2B

None established; no drugs known to target this molecule.