Target intelligence / Profile preview

RXYLT1 antisense RNA 1 (RXYLT1-AS1)

Target
RXYLT1-AS1
Molecular classification
Long non-coding RNA (lncRNA), Non-coding antisense RNA
01

Overview

RXYLT1 antisense RNA 1 (RXYLT1-AS1) is a long non-coding RNA (lncRNA) gene located on chromosome 12 and is transcribed as an RNA molecule but not translated into protein. It is also annotated as TMEM5 antisense RNA 1, reflecting its partial overlap or antisense relationship with the TMEM5 gene. There is currently limited functional characterization of RXYLT1-AS1, but as a member of the antisense lncRNA class, similar molecules are known to regulate the expression of protein-coding genes through mechanisms such as cis- or trans-modulation of their corresponding sense transcripts. RXYLT1-AS1 is associated in genetic databases with lissencephaly, but its direct role in disease or therapeutic targeting is not established. Current evidence places RXYLT1-AS1 in the "Other" category for molecular classification due to its nature as a lncRNA and lack of evidence classifying it under common druggable target families such as receptors, enzymes, or ion channels. No therapeutically relevant drugs, clinical mechanisms of action, or safety issues are described for this molecule. It is not a protein-coding gene, receptor, or established therapeutic target.

Other names
TMEM5 antisense RNA 1TMEM5-AS1
02

Mechanism of action

null

03

Biological functions

Regulation of gene expression (general function of antisense lncRNAs; no specific function for RXYLT1-AS1 demonstrated in literature as of this date)
04

Disease associations

Association reported with lissencephaly (a rare brain malformation)Other roles are unclear or uncharacterized

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