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Target intelligence / Profile preview
Ryanodine receptor 2 (RYR2)
- Target
- RYR2
- Molecular classification
- Ryanodine receptors, Intracellular ligand-gated ion channel
01
Overview
Ryanodine receptor 2 is an essential regulator of excitation–contraction coupling in heart muscle cells whose precise control ensures normal heartbeat rhythm; its dysfunction underlies several serious inherited heart diseases. It acts as the principal calcium-release channel on the sarcoplasmic reticulum membrane in cardiomyocytes, releasing stored Ca²⁺ into the cytosol upon electrical stimulation, which then initiates cardiac muscle contraction.
- Other names
- Cardiac ryanodine receptorRYR2 (human)hRyR2
02
Mechanism of action
Modulation of calcium release from the sarcoplasmic reticulum
03
Biological functions
Calcium ion releaseRegulation of cardiac muscle contractionExcitation-contraction couplingCalcium signalingRegulation of mitochondrial metabolismRegulation of gene expressionRegulation of cell survival pathways
04
Disease associations
Catecholaminergic polymorphic ventricular tachycardia (CPVT)Sudden cardiac death syndromesArrhythmiasCardiovascular disease
05
Safety considerations
ArrhythmiasInappropriate or excessive release of Ca²⁺ during diastoleLife-threatening arrhythmias
06
Interacting drugs
Caffeine
2 more in the full profile.
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