Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Ryanodine Receptor 2 (RyR2) (RyR2)
- Target
- RyR2
- Molecular classification
- Ion channel, Calcium channel, Receptor
01
Overview
The ryanodine receptor type 2 (RyR2) is the primary calcium release channel located on the sarcoplasmic reticulum (SR) of cardiomyocytes. It mediates calcium-induced calcium release, a crucial process in excitation-contraction coupling, where a small influx of calcium triggers a much larger release of calcium from the SR, initiating muscle contraction. Dysregulation of RyR2 is implicated in various cardiac pathologies, making it a significant therapeutic target.
- Other names
- Cardiac Ryanodine ReceptorSarcoplasmic reticulum calcium release channelRyR2 calcium release channel
02
Mechanism of action
Modulation of calcium release from sarcoplasmic reticulum
03
Biological functions
Calcium signalingExcitation-contraction couplingRegulation of intracellular calciumMuscle contraction
04
Disease associations
Heart failureCardiac hypertrophyCatecholaminergic polymorphic ventricular tachycardia (CPVT)Arrhythmia
05
Safety considerations
Arrhythmias due to aberrant calcium handlingPotential for drug-induced cardiac dysfunction
06
Interacting drugs
Ryanodine
Beyond the preview
Go deeper on Ryanodine Receptor 2 (RyR2) (RyR2).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Ryanodine Receptor 2 (RyR2) (RyR2).