Target intelligence / Profile preview

Ryanodine receptor 3 (RyR3)

Target: RyR3
Molecular classification: Ion channel, Calcium channel, Ryanodine receptor

Overview

Ryanodine receptor 3 (RyR3) is a calcium-activated calcium channel that mediates the release of Ca²⁺ from intracellular stores. It plays a role in controlling resting calcium ion concentration and participates in cytoplasmic Ca²⁺ signaling in various tissues. Unlike RyR1, RyR3 does not sustain excitation-contraction coupling on its own but may modulate it.

Other names: RYR3

Mechanism of action

Ryanodine binds to RyR3, locking it into an open subconductance state at low concentrations or inhibiting it at higher concentrations.

Biological functions

Calcium ion releaseRegulation of resting calcium concentrationCytoplasmic calcium signalingExcitation-contraction coupling modulation

Interacting drugs

Ryanodine

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