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Target intelligence / Profile preview
Ryanodine Receptor Channel (RyR)
- Target
- RyR
- Molecular classification
- Ion channel, Intracellular cation-selective ion channel, Receptor
01
Overview
The ryanodine receptor (RyR) is a giant, homotetrameric intracellular calcium release channel primarily located on the membranes of the sarcoplasmic reticulum (SR) in muscle cells and the endoplasmic reticulum (ER) in other cell types. It mediates rapid release of calcium ions from internal stores into the cytosol, a critical step for excitation-contraction coupling in muscles. RyRs are regulated by numerous factors including ions, small molecules, and proteins, and their dysregulation underlies several disorders like malignant hyperthermia and catecholaminergic polymorphic ventricular tachycardia.
- Other names
- Ryanodine receptorCalcium release channelSR calcium release channelEndoplasmic reticulum calcium release channel
02
Mechanism of action
Modulation of intracellular calcium release
03
Biological functions
Calcium signalingExcitation-contraction couplingMuscle contractionNeuronal excitabilityDifferentiationApoptosisATP productionCalcium homeostasis
04
Disease associations
Malignant hyperthermiaCentral core diseaseCatecholaminergic polymorphic ventricular tachycardiaCardiac arrhythmia
05
Safety considerations
Potential for arrhythmiasAltered intracellular calcium handlingMalignant hyperthermia susceptibility
06
Interacting drugs
Ryanodine
3 more in the full profile.
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