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Target intelligence / Profile preview
S-Adenosyl-L-homocysteine Hydrolase (SAHH)
- Target
- SAHH
- Molecular classification
- Enzyme, Hydrolase
01
Overview
S-Adenosyl-L-homocysteine hydrolase (SAHH), also known as AHCY, is an enzyme that catalyzes the reversible hydrolysis of S-adenosyl-L-homocysteine (AdoHcy) into adenosine and L-homocysteine. It plays a crucial role in regulating transmethylation reactions by controlling intracellular AdoHcy levels, a potent inhibitor of SAM-dependent methyltransferases. SAHH influences DNA, RNA, protein, and lipid methylation, impacting gene expression, signal transduction, and other cellular processes. Dysfunction of SAHH is linked to several diseases and metabolic disorders.
- Other names
- AHCYAdoHcy hydrolase
02
Mechanism of action
N/A
03
Biological functions
Regulation of transmethylationRegulation of methyltransferase activityEpigenetic regulationMethionine cycle regulation
04
Disease associations
Severe combined immunodeficiency (SCID)NeuroblastomaAgingMetabolic dysregulation
05
Safety considerations
Global hypomethylationDisruption of epigenetic regulationAltered homocysteine/adenosine levels
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