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Target intelligence / Profile preview
S-adenosylhomocysteine hydrolase (SAHH)
- Target
- SAHH
- Molecular classification
- Enzyme, Hydrolase
01
Overview
S-adenosylhomocysteine hydrolase (SAHH) is a highly conserved enzyme that catalyzes the reversible hydrolysis of S-adenosylhomocysteine (SAH) into homocysteine and adenosine. It plays a central role in cellular methylation processes and methionine metabolism by regulating the levels of SAH, a potent inhibitor of methyltransferases. AHCY mutations cause SAHH deficiency, leading to elevated methionine/creatine kinase levels and widespread inhibition of cellular methyltransferases. Pharmacologically targeting SAHH has been explored as an indirect means to modulate intracellular transmethylations.
- Other names
- AdoHcyaseAdenosylhomocysteinase
02
Mechanism of action
Inhibition of SAHH increases SAH levels, inhibiting methyltransferases.
03
Biological functions
Methionine metabolismRegulation of methylationRegulation of S-adenosylmethionine (SAM) levelsRegulation of homocysteine levels
04
Disease associations
Metabolic disordersGenetic disordersMethylation-related diseases
05
Safety considerations
Global methylation changesPotential for off-target effects due to widespread methylation regulationRare metabolic disorder
06
Biomarkers
Methionine levelsCreatine kinase levelsS-adenosylhomocysteine (SAH) levels
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