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Target intelligence / Profile preview
S-Adenosylmethionine Decarboxylase (AdoMetDC)
- Target
- AdoMetDC
- Molecular classification
- Enzyme, Decarboxylase
01
Overview
S-Adenosylmethionine Decarboxylase (AdoMetDC) is a critical enzyme in polyamine biosynthesis that catalyzes the conversion of S-adenosyl methionine to S-adenosylmethioninamine (decarboxylated S-adenosylmethionine). It is essential for cellular growth and function, and its activity is tightly regulated. AdoMetDC utilizes a covalently bound pyruvate residue as its essential prosthetic group for the decarboxylation reaction. Inhibitors of AdoMetDC have potential applications as anticancer and anti-trypanosomal agents.
- Other names
- S-Adenosylmethionine Decarboxylase (AdoMetDC)S-adenosylmethionine decarboxylase proenzymeSAMDCAdenosylmethionine Decarboxylase
02
Mechanism of action
Inhibition of S-Adenosylmethionine Decarboxylase, thereby reducing polyamine synthesis.
03
Biological functions
Polyamine biosynthesisCatalysisCellular growth regulationSpermidine synthesisSpermine synthesis
04
Disease associations
CancerParasitic diseasesCardiac hypertrophy
05
Safety considerations
Potential for toxicity due to dysregulation of polyamine levels.
06
Interacting drugs
AdoMetDC inhibitors
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