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Target intelligence / Profile preview
S-Adenosylmethionine Decarboxylase 1 (AMD1)
- Target
- AMD1
- Molecular classification
- Enzyme
01
Overview
S-Adenosylmethionine decarboxylase 1 (AMD1) is a key enzyme in the polyamine biosynthetic pathway, catalyzing the decarboxylation of S-adenosylmethionine (SAM) to produce S-adenosylmethioninamine (decarboxylated SAM). This product is essential for the synthesis of spermidine and spermine, which are critical for cell growth, proliferation, and DNA/RNA/protein synthesis. AMD1 is tightly regulated and plays a crucial role in diseases such as cancer and pulmonary hypertension, making it a potential therapeutic target.
- Other names
- Adenosylmethionine decarboxylaseAdoMetDC
02
Mechanism of action
Inhibition of S-adenosylmethionine decarboxylation, leading to decreased polyamine synthesis
03
Biological functions
Polyamine biosynthesisCell growthCell proliferationDNA synthesisRNA synthesisProtein synthesis
04
Disease associations
Cancer progression/maintenancePulmonary hypertension
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