S-adenosylmethionine decarboxylase 1 pseudogene

S-adenosylmethionine decarboxylase 1 pseudogene is a non-functional genomic DNA sequence similar to the gene for S-adenosylmethionine decarboxylase 1 (AMD1), an enzyme involved in polyamine biosynthesis. Pseudogenes do not produce functional proteins and are not considered valid therapeutic targets. The functional gene, S-adenosylmethionine decarboxylase 1 (AMD1), is an enzyme essential for polyamine synthesis and is associated with cell proliferation, but the "pseudogene" form has no known biological function or pharmacological relevance[1][9]. Pseudogenes such as this are segments of DNA that resemble functional genes but usually contain mutations or lack regulatory elements necessary for expression, so they are not translated into functional proteins[1][9]. Only the canonical gene product (S-adenosylmethionine decarboxylase 1; AMD1) is considered a target with known biological functions and therapeutic relevance. Information on enzyme activity, drug targeting, and pathway involvement refers to the functional AMD1 gene, not its pseudogenes[1][3][5][9]. ENSG00000218793 encodes a pseudogene, which lacks protein-coding capacity and is therefore not a therapeutic or functional biological target. If information on the active enzyme (AMD1) is required, it should be sought under the functional gene (e.g., ENSG00000123505)[1][9].